开这个博客的初衷是把它作为一个移动的笔记，将自己的一些学习工作上遇到的问题以及解决方案汇总于此。同时，也许会分享一些生活中的事情吧。
About me
Hi, I’m Yuan SHANG. I’m a Bioinformatician in Dr.Roberta Brinton’s Lab at CIBS (https://www.cibs.uahs.arizona.edu/).
Main research interests
• Precision medicine • Multi-omics • Big data • Alzheimer’s Disease
Current Projects
My current research is mainly focusing on computational biology, searching for new therapeutic opportunities for Alzheimer’s Disease:
• Develop multi-scale network integration methods to explore potential beneficial mechanisms in drug development. I integrated all previous accumulated various omics data of both animal models and phase I clinic trial human datasets in the lab, and found potential mechanisms of how that drug could improve the patients. Network approach explains very well how our drug works. Together with all our other results, our phase 2 clinic trial was approved in August 2019.
• Explore new drug targets for Alzheimer’s Disease. My current effort is mainly focusing on disease classification based on various publicly available datasets (including genomics, epigenomics, transcriptomics, proteomics and metabolomics). Alzheimer’s has distinct pathologies based on the multi-omics network, and I’m building prediction model based on network and machine learning techniques. This work would definitely advance the field of personalized medicine and would lead to new drug targets for specific Alzheimer’s subtype.
• Develop Novel factors that affect Alzheimer’s Disease progressions. Our data showed that life style and medicine treatment could affect AD progression dramatically. With the early access to the clinic data in AllOfUs dataset, together with UKbiobank dataset, I’m now actively exploring novel factors that affect the progressions of Alzheimer’s disease using machine learning approaches.
